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*Haugland ML, Collier M, DeBault LE, et al, H-PSGAG concentration in the synovial fluid of the equine antebrachiocarpal, metacarpophalangeal, coronopedal and tibiotarsal joints following a 500 mg IM injection.
The Journal of Equine Vet Science; 15(6), 1995.
**Burba D, Collier M, DeBault LE, et al, In Vivo Kinetic study
on uptake and distribution of intrmuscular tritium-labeled Polysulfated Glycosaminoglycan in equine body fluid compartments and articular cartilage in an osteohealth defect model.
The Journal of Equine Vet Science; 13(12), 1993.
Proof that Adequan® i.m. (Polysulfated glycosaminoglycan) stimulates cartilage repair and reverses traumatic joint dysfunction
2 hours
After intramuscular injection, therapeutic levels peak in knee and hock joints.*
Within 48 hours
The hyaluronic acid (HA) in the synovial fluid nearly doubles after a single injection.* Recommended dose: 5 mL every 4 days for 7 treatments intramuscularly.**
4 days
After a single intramuscular injection, this potent enzyme inhibitor is still detected in cartilage and subchondral bone.**
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